Seraseq FFPE BRCA 1/2 LGR Reference Material (NEW)Genetic testing of the tumor suppressor genes BRCA1 and BRCA2 allows for the identification of DNA variants which are associated with a significantly elevated lifetime risk of breast, ovarian, pancreatic and prostate cancer. Large genomic rearrangements (LGRs) include deletions, duplications and or insertions often involving whole exons. Usually pathogenic, they have been reported to account for up to 27% of the overall BRCA11 and 5% of BRCA2 disease